Thymol boils at 230° C. (446° F.) (Doveri and Lallemand). An increase in the quantity of urine was frequently noticed; and the urine presented a dark, greenish color, as if it contained blood, and appeared a yellowish-brown when illuminated by reflected light. "A phenol occuring in the volatile oils of Thymus vulgaris, Linné, Monarda punctata, Linné (Nat.
It is also soluble in strongly alkaline aqueous solutions due to deprotonation of the phenol. Media related to Thymol at Wikimedia Commons, Chemical compound found in plants including thyme, InChI=1S/C10H14O/c1-7(2)9-5-4-8(3)6-10(9)11/h4-7,11H,1-3H3, InChI=1/C10H14O/c1-7(2)9-5-4-8(3)6-10(9)11/h4-7,11H,1-3H3, Except where otherwise noted, data are given for materials in their, Environmental breakdown and use as a pesticide, CS1 maint: multiple names: authors list (, CAS Registry: Data obtained from SciFinder. [9] The ancient Greeks used it in their baths and burnt it as incense in their temples, believing it was a source of courage.
[18] Thymol demonstrates in vitro post-antibacterial effect against the test strains E. coli and P. aeruginosa (gram negative), and Staphylococcus aureus and B. cereus (gram positive). Thyme was also used as incense and placed on coffins during funerals, as it was supposed to assure passage into the next life. Its specific gravity, as a solid, is 1.069 at 15° C. (59° F.), but when liquefied by fusion it is lighter than water. When much hyperemia is present, it must not be applied until this has been allayed. Thymol can be found in several botanical oils. 58–59. It … It is also soluble in strongly alkaline aqueous solutions due to deprotonation of the phenol. Take a 1 pint (473ml) bottle of 91% alcohol, mark the fill level, then pour the alcohol out. Then weigh 59g of thymol crystals, and pour them carefully into the empty bottle.
It is not necessary to employ too strong a solution, as pure thymol possesses caustic properties.
[20], Thyme essential oil is useful in preservation of food. Soluble in about 1200 parts of water at 15° C. (59° F.), and in less than its own weight of alcohol, ether, or chloroform; also readily soluble in carbon disulphide, glacial acetic acid, and in fixed or volatile oils. http://www.henriettes-herb.com - Copyright 1995–2020 Henriette Kress. In making solutions of thymol with glycerin and water, it is best to triturate the thymol in a mortar with a small portion of alcohol, until it is dissolved, then add the desired menstruum. Linear Formula 2-[(CH 3) 2 CH]C 6 H 3-5-(CH 3)OH . The spread of thyme throughout Europe was thought to be due to the Romans, as they used it to purify their rooms and to "give an aromatic flavour to cheese and liqueurs". A cathartic is administered at night, and 10 grains of thymol administered in the morning every 15 minutes until the worm is expelled.
This has been found to act efficiently, even in cases in which iodine and other analogous topical applications had been fruitlessly employed. Functional nervous and neuralgic headaches, and mental and other nervous disorders have been successfully treated with it. Blackie Academic Professional; London, UK: 1995. pp. S. P.). It should be kept in well-stoppered bottles"—(U. S. P.). This latter is held in the patient's mouth, who will aspire the air charged with the vapor of the thymol. A liquid that contains Thymol, Dimethylsulfoxide (DMSO), and alcohol. It has a fragrant, aromatic odor, a ungent taste, and in reaction is slightly acid. [25] Thymol is also used as a rapidly degrading, non-persisting pesticide. In the majority of cases, half an hour or an hour after the ingestion of thymol, more or less limited and profuse sweats appeared, but in all cases less than those occasioned by salicylic acid or jaborandi. The spread of thyme throughout Europe was thought to be due to the Romans, as they used it to purify their rooms and to "give an aromatic flavour to cheese and liqueurs". MOLECULAR WEIGHT: 149.66. of a 10 per cent solution of sodium hydrate, a clear, colorless, or very slightly reddish solution should be formed, which becomes darker on standing, but without the separation of oily drops (absence of thymen, or laevogyrate pinene (C10H16). [16], An in vitro study found thymol and carvacrol to be highly effective in reducing the minimum inhibitory concentration of several antibiotics against zoonotic pathogens and food spoilage bacteria such as Salmonella typhimurium SGI 1 and Streptococcus pyogenes ermB. It mixes clear with water in all proportions. In: Natural Antimicrobials from Plants. Beilstein/REAXYS Number 1907135 . [27], In 2009, the U.S. Environmental Protection Agency (EPA) reviewed the research literature on the toxicology and environmental impact of thymol and concluded that "thymol has minimal potential toxicity and poses minimal risk".[41]. [16], An in vitro study found thymol and carvacrol to be highly effective in reducing the minimum inhibitory concentration of several antibiotics against zoonotic pathogens and food spoilage bacteria such as Salmonella typhimurium SGI 1 and Streptococcus pyogenes ermB. Tests. In: Natural Antimicrobials from Plants.
It is found in oil of thyme, oil of horsemint, and oil of Carum Ajowan, De Candolle (Ptychotis Ajowan), a plant from the East Indies; the thymol of commerce being derived from thyme oil. [17] In vitro studies have found thymol to be useful as an antifungal against food spoilage and bovine mastitis. Thymol has a refractive index of 1.5208[4] and an experimental dissociation exponent (pKa) of 10.59±0.10. In making solutions of thymol with glycerin and water, it is best to triturate the thymol in a mortar with a small portion of alcohol, until it is dissolved, then add the desired menstruum. Allow to dry. [21], The antifungal nature of thymol against some fungi that are pathogenic to plants is due to its ability to alter the hyphal morphology and cause hyphal aggregates, resulting in reduced hyphal diameters and lyses of the hyphal wall. [13], Thymol was first isolated by the German chemist Caspar Neumann in 1719. [24] Thymol is also the active antiseptic ingredient in some toothpastes, such as Johnson & Johnson's Euthymol. Source, History, and Preparation.—Thymol was discovered by Caspar Neumann in 1719. Thymol also provides the distinctive, strong flavor of the culinary herb thyme, also produced from T. vulgaris. It is very extensively employed in the antiseptic treatment of operative and accidental wounds, and as a general cleansing agent in medical and dental practice.
Each of CleanWell's thymol cleaning products contains a 0.05% concentration of thymol and is designed to kill 99.9% of germs, bacteria, and viruses. COVID-19 is an emerging, rapidly evolving situation. Formula: C₂₇H₃₀O₅S MW: 466.6 g/mol Storage Temperature: Ambient: MDL Number: MFCD00005869 CAS Number: 76-61-9 EINECS: 200-973-3 UN: 1170 ADR: 3,II: Order Now. It combines the properties of phenacetin with the antiseptic power of thymol. Thymol blue. Thymol is a component found in thyme oil, which is a naturally occurring mixture of compounds from, yup, the thyme plant, according to the EPA.
Ten drops of the solution will suffice for inhalation during 4 or 5 days. Ecotoxicol.Environ Saf 2009;72(3):943-947. [10] In the European Middle Ages, the herb was placed beneath pillows to aid sleep and ward off nightmares. Mix thoroughly, and divide into 20 pills. M., Ph. Mix. Press and Circ.).
[citation needed] It is also used as a preservative in halothane, an anaesthetic, and as an antiseptic in mouthwash. of glacial acetic acid, and then 6 drops of sulphuric acid and 1 drop of nitric acid be added, the liquid will assume a deep bluish-green color. M. Paquet has preserved viscera, portions of limbs, etc., free from the least trace of putrefaction for several months, by means of the following solution: Take of thymol, tannin, each, 1 drachm; anilin, ½ drachm; glycerin, 3 ounces.
Thymol has been employed in inhalations, by Bouillhon, Paquet, and others, in bronchial and other affections of the respiratory organs, attended with gangrenous exhalations. Thymol exists in oil of thyme, associated with two hydrocarbons of greater volatility, cymol (C10H14), and thymene (C10C16) (see Oleum Thymi). Animals poisoned with it pass into a deep coma; after death their blood is dark and fluid, but no fatty degeneration of internal organs is observed (Med. [citation needed] It is also used as a preservative in halothane, an anaesthetic, and as an antiseptic in mouthwash. Thymol is a phenolic monoterpene that has received considerable attention as an antimicrobial agent with very high antifungal activity and very low MIC values 13 and as a possible food antioxidant. The yield of thymol from this source, however, is comparatively small and quite variable (from less than 1 to 38 per cent; see Amer. B. [21], The antifungal nature of thymol against some fungi that are pathogenic to plants is due to its ability to alter the hyphal morphology and cause hyphal aggregates, resulting in reduced hyphal diameters and lyses of the hyphal wall. XIV, Parts III and IV). Analgesic properties are also possessed by it. In doses of from 30 to 60 grains, M. Baelz considers its action, as an antipyretic, decidedly inferior to that of salicylic acid. The nervous phenomena were represented by tinnitus aurium, deafness, and a sense of constriction at the temples (Archiv der Heilkunde, Vol.
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